Bleeding tendency IP 121/ASTMD 1742  [c.310]

If glass is still thought to be present in the cut, wash thoroughly before applying pressure. If bleeding is profuse, the application of pressure to prevent bleeding is more important than the removal of the glass.  [c.527]

For serious cuts, send for a doctor at once meanwhile wash with a disinfectant and endeavour to check bleeding by applying pressure immediately above the cut. Continuous pressure should not be maintained for more than five minutes.  [c.1132]

In any case, I eventually recovered (and so did Jerry), but my immune system must have suffered serious damage, which manifested itself three years later, when I collapsed in my office one day and was found to be bleeding internally from a form of rare stomach cancer, which necessitated major surgery but was fortunately localized. I again recovered and have had no further difficulties since. Whether weakening and knocking out my immune system to overcome the previous problems had any effect is not clear, but it could have been a factor. Despite my health problems I was able to continue my work without much interruption, and the scientific productivity of my group has not  [c.117]

If glass is still thought to be present in the cut, wash thoroughly before applying pressure. If bleeding is profuse, the application of pressure to prevent bleeding is more important than the removal of the glass.  [c.528]

Plasticizers are relatively nonvolatile liquids which are blended with polymers to alter their properties by intrusion between polymer chains. Diisooctyl phthalate is a common plasticizer. A plasticizer must be compatible with the polymer to avoid bleeding out over long periods of time. Products containing plasticizers tend to be more flexible and workable.  [c.1011]

The FD C certified colors are all water-soluble dyes, but can be transformed into insoluble pigments known as lakes by precipitating the dyes with alurninum, calcium, or magnesium salts on a substrate of aluminum hydroxide. The lakes are useful in appHcations that require color whereas in dry form, such as cake mixes, or where water may be present and bleeding is a problem, such as food packaging. FD C Red Lake No. 3 was deHsted in Febmary  [c.437]

Platelets. Blood platelets play a key role in the prevention of blood loss from intact vessels, and the arrest of bleeding from injured vessels.  [c.520]

Inks. Typical inks are water-based, with acryUc emulsion resins as the main binder. Inks of this type occasionally use natural products such as starches, lignins, and lignin derivatives. Hence, ecologically, this process is more desirable. Practically all resins used in this ink system are rendered water soluble or emulsiftable through neutralization with organic amines. Strong absorption of amine by the newsprint renders the resin, after printing, water insoluble and prevents bleeding of printed matter. Press ready inks are very fluid and of low viscosity. Inks contain a variety of additives for the elimination of foaming, dispersion of pigments, rheological modifiers, sHp agents, etc.  [c.250]

Bleeding of nuclear fuel was recognized as having a potentially important impact on the avadabihty of energy resources as soon as plutonium was  [c.220]

The choice of a pigment for a specific plastic appHcation also depends on its resistance to solvent and its insolubiHty in the polymer used. The phenomenon of migration, which includes the effects of bleeding and blooming, results from the partial dissolution of pigment in the polymer system at the processing temperature. Organic pigments generally satisfy the lightfastness requirement, but it is possible that a certain pigment may fade badly on exposure to light, although it is perfectly stable in the other dispersion systems.  [c.515]

Bleeding properties ate also a function of solubiUty of a pigment in a vehicle, plasticizer, or solvent. Blooming is another manifestation of solubiUty whereby dissolved pigment migrates from within a pigmented medium to its surface where it is redeposited as pigment crystals and can be readily mbbed off. This is quite prevalent in the coatings (qv) and printing industry.  [c.23]

Patients immediate post-operative pain is lower compared to a standard operation and healing and rehabiUtation more rapid. Patients can resume near-normal activities in just days. In some cases athletes, who are in prime physical condition, can return to challenging athletic activities within a few weeks. CompHcations are rare, but do occur on occasion. Most complications associated with this surgery are infection, phlebitis, excessive swelling or bleeding, blood clots, or damage to blood vessels or nerves.  [c.190]

Petroleum plasticizers are the most universally used plasticizers for all mbber compounds. They improve flow and processing characteristics and also reduce the cost of the final compound. Aromatic process oils are the most common plasticizer for general-purpose mbbers. Naphthenic process oils are used where a minimum of discoloring or staining is required. AUphatic process oils are used in the low polarity mbbers where high loadings and good solubihty are required to avoid bleeding and maximize the plasticizing action.  [c.245]

Sludge-blanket clarifiers are available in flat-, trough-, and hopper-bottom types. The hopper-bottom vertical-flow clarifier shown in Figure 5 achieves rise rates of 1—6 m/h in wastewater appHcations. It is a 3—4 m deep, 60° triangular or circular hopper tank, with feed introduced through a downward-pointing inlet at the bottom of the tank. The flocculated feed suspension is clarified by passage through the blanket and overflows into decanting troughs that are usually 1—1.5 m above the blanket, to allow for blanket-level variations with feed flow rate. The blanket can be continuously bled off through a submerged weir-type regulator and then thickened in a conical concentrator, or the clarifier can be periodically shut down to allow settlement bleeding.  [c.321]

Other Inks. The alkan olamine titanates, such as TYZOR TE, when mixed with a coloring agent used to print fibrous materials such as cotton, wool, or silk, promote adhesion of the dye molecule to the fiber, thus minimizing bleeding of the printed design (511).  [c.163]

Deficiency of Factor VII is relatively rare and inherited as an autosomal recessive disorder. Deficiency of Factor VII has been reported to be associated with bond abnormal bleeding and thrombotic tendencies. Deep vein thrombosis and pulmonary emboli have been reported in affected individuals. There is a very high frequency of Factor VII deficiency in people with the Dubin-Johnson syndrome, which is a congenital disorder of Hver function.  [c.174]

Because colestipol and cholestyramine are not absorbed, but simply pass through the body by the GI tract, few severe side effects occur. Patients often complain of distaste and constipation, however. More severe side effects such as GI bleeding ate relatively uncommon (151).  [c.131]

For more serious cuts, where bleeding is profuse, apply pressure with a thick sterile (or at least clean) pad, dressing, or towel over the area. If an arteiy is spurting, try to minimise bleeding by applying pressure immediately above and below the cut.  [c.527]

For more serious cuts, where bleeding is profase, apply pressure with a thick sterile (or at least clean) pad, dressing, or towel over the area. If an artery is spurting, try to minimise bleeding by applying pressure immediately above and below the cut.  [c.528]

An example that illustrates the exquisite nanoscale complexity of a membrane protein system is the glycoprotein (GP) Ib-IX-V complex found on the surface of human platelets blood-home cell-like protoplasmic disks whose primary function is arresting blood loss (hemostasis). The surface of a platelet is covered with several types of glycoprotein complexes, of which the GP Ib-IX-V is the second most abundant (after GP Ilb-IIIa) typically, approximately 25,000 copies of the complex reside on the platelet plasma membrane. The complex performs several important processes that contribute to the hemostatic functions of platelets vide infra), each of which is vital to the well-being of the human organism. Genetic defects resulting in the nonexpression of the complex result in the most common form of the bleeding disorder, Bemard-SouHer syndrome (64).  [c.200]

Biochemical studies of the GP Ib-IX-V complex have identified several distinct functions of particular components of the complex that are related to the platelet s role in hemostasis. These include the binding of von Wikebrand factor (vWf) that is immobilized on the vascular subendotheHum (ie, the blood vessel wall), and the binding of thrombin. One of the most remarkable features of these interactions is that they are regulated so that they normally occur only when hemostasis is needed, ie, during bleeding. For example, it has been shown that GP Ib will bind vWf when vWf is immobilized on the vessel wall, and not when vWf is in solution in the plasma where it circulates along with the platelets. The abiUty of GP Ib to discriminate bound versus unbound vWf is thought to be related to the increased shear rates to which the platelet is subjected in flow near stationary surfaces. Thus, in addition to functioning as a molecular sensor and transducer (ie, transducing activation signals after vWf and thrombin binding), the GP Ib-IX-V complex is likely to serve as a mechanical sensor as well, whose molecular recognition capacity is activated only in the proper shear environment.  [c.201]

Toxicity and Environmental Considerations. Prolonged exposure and skin contact with TNT in the workplace may lead to rashes, skin emptions, and more serious consequences such as nose bleeds and hemorrhage of the skin, as well as mucose and blood disorders. Dust inhalation may result in nausea, vomiting, toxic hepatitis, and anemia. Occupational cleanliness is critically important in TNT manufacture. Wastewater from TNT contains mostiy dissolved TNT and possible traces of dinitrotoluene and isomers of TNT. The water from loading plants generally contains TNT, HMX, RDX, and wax. The washings initially are colorless but turn pink if neutral or basic and exposed to sunlight. The dissolved products are removed by filtration through diatomaceous earth (see Diatomite) and activated carbon. The disposal of the explosive-contaminated carbon by open burning or as landfill ia hazardous waste sites is increasingly unacceptable. An alternative process possible for future appHcation consists of usiag ozone (qv) ia the presence of uv light to decompose the organics ia the pink water. Red water is produced ia the selliting process, and has been either burned ia rotary kiln separators or sold to the paper iadustry. These options are no longer viable, and alternative approaches are under study including process changes and modifications of current iaciaeration technology (189—204).  [c.18]

Carburetor Detergents. Carburetors were the most common form of fuel metering device in automobiles until the mid-1980s when these were replaced to a large extent by throttle-body and port fuel injectors. Deposits can form on and around the throttle plate and adjacent throat area. Deposits in this region can cause poor fuel distribution and atomi2ation at idle and low speed operation because the deposits interfere with air flow past the throttle. Deposits in the throat can clog air bleeds or idle jets and can upset the desired stoichiometry in the engine. The deposits are thought to be caused by the oxidation of unstable or partially oxidi2ed fuel components reacting with materials found in the crankcase blowby and the exhaust gases which are recycled to control NO emissions. The deposit-forming tendency of fuels is determined using a bench engine which is mn under strictly controlled conditions of temperature, humidity, crankcase blowby, and exhaust gas recycle (EGR) (42).  [c.186]

Cimetidine was the first histamine-H antagonist approved in the United States. Its mechanism of action is suppression of gastric acid secretion through the blockade of histamine H2 receptors on the gastric parietal cells, thereby decreasing both basal and stimulated gastric acid secretion. It is indicated for short-term treatment of active duodenal ulcer, maintenance therapy for duodenal ulcer at reduced dosage, short-term treatment of active benign gastric ulcer and erosive gastroesophageal reflux disease, prevention of upper gastrointestinal bleeding in critically ill patients, and treatment of pathological hypersecretory conditions. Cimetidine has been reported to inhibit certain microsomal enzyme systems and reduce the fiver metabolism of a large number of dmgs. There should be careful monitoring of patients on concomitant therapy with other dmgs, eg, antiasthmatic agents (qv).  [c.199]

For arresting hemorrhage during surgery, a special sterile gelatin sponge known as absorbable gelatin sponge (23) or Gelfoam is used. The gelatin is partially insolubiH2ed by a cross-linking process. When moistened with a thrombin or sterile physiological salt solution, the gelatin sponge, left in place after bleeding stops, is slowly dissolved by tissue en2ymes. Special fractionated and prepared type B gelatin can be used as a plasma expander.  [c.208]

The utems is exceptionally sensitive to the effects of estrogens and progestins. Estrogens stimulate the proliferation and vascularization of the uterine endometrium (see Hormones, estrogens and antiestrogens). Progestins serve to suppress the stimulatory effects of estrogen on uterine growth, an effect termed antiestrogenic. Progestins blunt the responsiveness of the utems to estrogen by reducing estrogen receptor levels in the utems (264,265). In addition, progestins affect estrogen metaboHsm within the utems by inducing 17P-hydroxysteroid dehydrogenase which converts estradiol to the inactive estrone (266). Morphologically, the uterine effects of progestins can be seen as a reduction in the number and size of endometrial glands and a decrease in the proliferation of both glandular and stromal cells (253,267,268). Progestins also act on the uterine myometrium reducing the frequency of contractions (269). In nonpregnant women, menstmal bleeding is the most noticeable effect of progestins on the lower reproductive tract. After being transformed from a proliferative to a secretory state by the action of progesterone or a synthetic progestin, the uterine endometrium requites constant steroidal stimulation or it regresses and is lost in menses. Intermenstmal bleeding, or breakthrough bleeding, is a common side effect with the use of synthetic progestins, as in oral contraceptives. Elsewhere within the lower reproductive tract, progestins have other effects. The quantity of cervical mucus is lessened and the mucus is more viscous under the influence of progestins (253). The motility of the oviduct is affected by progestins which can act to delay the transport of ova from the ovary to the utems (270).  [c.222]

Estrogen Deficiency. Treatment with cycHc estrogen has been proven to benefit young women with estrogen deficiency, caused by primary ovarian failure or by hypogonadotropic hypogonodoHsm resulting from luteinizing hormone-releasing hormone (LH-RH) deficiency or hypopituitarism (103,104). The therapy should be initiated at the time of expected puberty for the promotion and maintenance of female sexual characteristics. The breasts and endometrium respond to only a high dosage of ethinyl estradiol. Low dosage estrogen therapy is used to promote the growth of the long bones. Estrogen is usually prescribed in a cycHc fashion with an initial dose of 0.3 mg/d of conjugated estrogens until growth ceases, at which time the daily estrogen dose is increased to 0.625—1.25 mg to augment breast development. Adding a progestogen at the time of the first breakthrough bleeding episode could induce cycHcal withdrawal bleeding (105,106).  [c.243]

Estrogen replacement is successful in treating the symptoms in menopause (vasomotor symptoms and vaginal atrophy) and has been reported to reduce the risk of osteoporosis and atherosclerotic heart disease (110). A recent study suggests that estrogen replacement treatment prevents increases in abdominal fat that occur after menopause (111). Eor long-term use estrogens should be given in the minimally effective dose (0.625 mg conjugated estrogen, 0.625 mg estrone sulfate, or 1 mg of micronized estradiol) (112,113). The hormones are given oraUy or in estrogen-containing vaginal cream or transdermal estradiol patches. Progestogens given cycUcaUy (10 14 d/mo) are recommended to avoid withdrawal bleeding (114) and to minimize the risk of endometrial cancer (115,116). Estrogens are most effective for the reUef of vasomotor symptoms. The symptoms of genitourinary atrophy improve with estrogen replacement therapy of aU forms, and it has been suggested that estrogens could be given before atrophy occurs.  [c.243]

Adverse Effects. The side effects of estrogens vary according to the type and dosage of the estrogen and if progestins are co-adininistrated. The most common side effect is nausea. However, it does not usually interfere with eating and cause weight loss. Increasing the dosage may further induce anorexia and vomiting. Breast enlargement, enlargement of endometrial tissue, and intermenstmal bleeding are other common side effects. Low dose estrogens, such as multiphasic oral contraceptives which contain 30—35 p.g of estrogen and new versions of progestogen, significantly reduce intermenstmal bleeding (153).  [c.245]

Tests using rabbits indicate that transition from an eye irritant to a corrodant occurs at about 10% H2O2. At strengths 10% and above, a splash in the eye can cause severe ulceration and kreversible corneal damage unless flushed immediately with water. Inhalation of concentrated vapors can cause irritation of the nose and throat with chest discomfort, cough, difficult breathing, and shortness of breath. Ingestion can cause irritation of the gastrointestinal tract with pain, bleeding, and, distension of the stomach and esophagus, resulting from the hberation of oxygen. Gross overexposure by ingestion may be fatal. No component in industrial hydrogen peroxide solutions is Hsted as a carcinogen.  [c.480]

Corticosteroids (60) are used to treat some patients with severe progressive RA. Low dose prednisone (18) may be a better alternative to second-line therapy for the elderly. In younger patients, disease control may be desired temporarily until second-line dmgs, with a slower onset, can provide sufficient control. For patients who cannot tolerate NSAIDs or have severe systemic manifestations of RA, such a pericarditis or vasculitis, prednisone may be helpful. Intraarticular injections of corticosteroids are often helpful in treating acute inflammation of RA joints. There are many adverse side effects of corticosteroids. These include osteoporosis, cataracts, poor healing, gastrointestinal bleeding, hyperglycemia, hypertension, and increased infection. Gastrointestinal bleeding and osteoporosis may be more severe in the elderly.  [c.40]

Pharmaceuticals. The concept of microencapsulation has intrigued the pharmaceutical industry for many years, because it offers the possibihty of providing a number of important new oral and parenteral dosage forms. Microcapsules in oral dosage forms could conceptually taste-mask bitter pharmaceuticals, provide extended release in vivo, provide enteric release, improve the stabiUty of incompatible dmg mixtures, provide resistance to oxidation, reduce volatiUty, and distribute a dmg in many small carrier particles so that effects of the dmg on the sensitive walls of the stomach ate minimized. Microencapsulated parenteral formulations could provide prolonged deUvery of dmgs with short half-Hves in vivo and perhaps even achieve targeted dmg deUvery. For these reasons, microencapsulation has received much attention by pharmaceutical scientists (44). Several mictocapsule-based oral pharmaceutical formulations which offer some of these features ate available. AH have an ethylceUulose shell and ate produced by a polymer—polymer phase-separation process carried out in hot cyclohexane (8). The cote material is a soHd that has finite solubiUty in water. Encapsulated potassium chloride, KCl, has been used extensively because the KCl dispersed in many small ethylceUulose capsules minimizes high localized concentrations of KCl in the stomach that can irritate the lining of the stomach and induce bleeding. Aspirin encapsulated in ethylceUulose for arthritic patients is an example of using microencapsulation to extend time of release of a dmg in the gastrointestinal tract (see Gastrointestinal agents). In this case, the encapsulated aspirin formulation provides overnight reUef FinaUy, encapsulated oral acetaminophen formulations for chUdren ate used to provide taste-masking.  [c.324]

Iron Deficiency and Toxicity. Iron deficiency is a significant worldwide nutritional problem and cause of anemia which can also lead to a decreased resistance to infection. Insufficient dietary iron intake iron losses, eg, bleeding and parasite infestation and malabsorption of iron are the principal causes. The groups at greatest risk for developing iron-deficiency anemia are menstmating females, pregnant or nursing females, and young children. Children can experience impaired psychomotor development and intellectual performance.  [c.384]

Toxicity. Many /V-nitrosamines are toxic to animals and cells in culture (4,6—8,88). /V-Nitrosodimethy1amine [62-75-9] (NDMA) is known to be acutely toxic to the Hver in humans, and exposure can result in death (89). Liver damage, diffuse bleeding, edema, and inflammation are toxic effects observed in humans as a result of acute and subacute exposure to NDMA. These effects closely resemble those observed in animals dosed with NDMA (89,90).  [c.109]

Polypropylene fibers are neither dyeable by conventional methods nor readily stained because dye receptor sites do not naturally exist along the molecular backbone. However, some spunbonded polypropylene fabrics are colored by the addition of a pigment to the polymer melt wherein the pigment becomes encased within the fiber interior. Advantages to this method include higher resistance to fading and bleeding and ease of reproducibiUty of color shades from lot to lot. A key disadvantage is the generation of small to large quantities of off-quaUty production during the transitions into and out of a particular color. A delustering pigment, eg, Ti02, is often added to polypropylene as it almost always is with the manufacture of nylon fibers.  [c.163]

Aluminum chloride hydrate is used ia textile finishing to impart crease recovery and nonyellowing properties to cotton (qv) fabrics, antistatic characteristics to polyester, polymide, and acrylic fabrics, and to improve the fiammabiUty rating of nylon (see Textiles). Dye-bleeding of printed textile may be blocked (17) by treatment with aluminum chloride and 2iac acetate, Zn(02CCH2)2, followed by so1iihi1i2ing with ethylenediamine tetraacetic acid, and washing from the fabric.  [c.149]

Aspirin, the oldest of the nonsteroidal antiinflammatory dmgs (NSAIDs), is a member of the sahcylate group. SahcycHc acid, isolated in 1838 from willow bark, was commonly used throughout the Middle Ages for the treatment of headaches. Its therapeutic benefits were well known even to Hippocrates. Many derivatives have been prepared to reduce the irritation associated with the pure acid. The most common form is acetylsahcycHc acid [50-78-2] (18). Aspirin is an effective treatment for pain, fever, and for symptoms of acute inflammation. It is often the first treatment for the pain and swelling associated with rheumatoid arthritis. Because of its frequent usage, there are over 10,000 cases of serious sahcylate intoxication in the United States every year. Many of these cases involve children, and some are fatal. High doses or chronic use of aspirin may aggravate peptic ulcer symptoms, generate gastric ulceration and bleeding, and produce acid-base and electrolyte imbalance.  [c.385]

A second class of NSAIDs, the so-called coal tar analgesics, are derived from acetanilide ( 16, R = H). Although it is no longer used therapeutically, its analogues, phenacetin (16, R = OC2H ) and the active metaboUte, acetaminophen (16, R = OH) are effective alternatives to aspirin (47). They have analgesic and antipyretic effects that do not differ significantly from aspirin, but they do not cause the gastric irritation, erosion, and bleeding that may occur after saUcylate treatment. In contrast to aspirin, however, they are not cyclooxygenase inhibitors and have no antiinflammatory properties. Clinically acetaminophen is preferred over phenacetin, because it has less overall toxicity.  [c.386]

Supplemental vitamin A, begun prior to or directiy after local irradiation (30 Gy (3000 rad) to the hind limb), decreases radiation-induced toxicity. Supplemental vitamin A or -carotene also diminishes systemic toxicity owing to local x-radiation in tumor-bearing mice without diminishing the antitumor effect of the radiation. In addition to the effects on lethahty (LD q q) survival time, these vitamins also protect rodents against gastric and intestinal bleeding, adrenal gland hypertrophy, thymic involution, lymphocytopenia, weight loss, and carcinogenesis. Vitamin A and -carotene can stimulate immune reactions, including those directed against tumors. In some instances this results in an enhanced antitumor effect of local irradiation (93).  [c.491]

The potential for combining vitamins and aminotbiols shows some promise. Vitamin E (100 lU/kg) injected subcutaneously (sub-q) either 1 h before or within 15 min after irradiation significantly increases the 30-day survival of mice. Improved protection has been obtained when WR-3689 (150—225 mg/kg) is also given ip 30 min before irradiation (101). Preirradiation treatment using vitamin E and cysteine in combination also offers better radioprotection than the individual agents against alterations in various hematological parameters (102). An additional potential benefit is that vitamin A and P-carotene may actually inhibit some of the side effects, such as ulceration and bleeding, associated with the use of aminothiols (93).  [c.491]

Sex Hormones. The largest economic impact of synthetic estrogen and progestin production has been for use as contraceptive agents and for treatment and prevention of osteoporosis. Mixtures of estrogens and progestins have been used as contraceptive agents since the early 1960s. The principal mode of steroid contraceptive action is exerted at the hypothalamic—pituitary—ovarian and uterine sites. Thus, contraceptive steroid mixtures have been used to treat a variety of related abnormal states including endometriosis, dysmenorrhea, hirsutism, polycystic ovarian disease, dysfunctional uterine bleeding, benign breast disease, and ovarian cyst suppression (233). One of two estrogens, ethinylestradiol [57-63-6]  [c.444]

Deficiency. Scurvy is a vitamin C-speciftc disease. It is characterized by anemia and alteration of protein metaboHsm weakening of coUagenous stmctures in bone, teeth, and connective tissues swollen, bleeding gums with loss of teeth fatigue and lethargy rheumatic pains in the legs and degeneration of the muscles, skin lesions, and capillary weakness, massive hematomas in the thighs and hemorrhages in many organs, including the eyes. Small (10—60 mg/d) quantities of L-ascorbic acid are sufficient to reverse the trend of both subclinical and clinical scurvy and alleviate their symptoms. Plasma and leukocyte ascorbic acid levels are the most reHable markers of vitamin C intake. Leukocyte levels are more reHable, less sensitive to recent vitamin C intake, and better reflect tissue ascorbate, but require relatively large amounts of blood. Normal leukocyte vitamin C levels are 20—40 p.g/10 cells (148). Plasma concentrations of ascorbic acid less than 0.2 mg/dL and leukocyte concentrations below 2 p.g/10 cells are seen in scurvy (149). Plasma ascorbic acid levels of 0.5 mg/dL are considered to prevent deficiency symptoms. Normal plasma levels are 0.8—1.4 mg/dL.  [c.22]

Generally, nephrotoxicity is not a problem. Some cephalosporins, especially those with the 3-methylthiotetrazole side chain, such as moxalactam (48), show a tendency to promote bleeding. This appears to be due to a reduction in the synthesis of prothrombin and can be a problem especially in elderly patients, patients with renal insufficiency, or patients suffering from malnutrition (219). The same side chain seems to promote a disulfiramlike reaction in patients consuming alcohol following a cephalosporin dose (80,219).  [c.39]

In chronic benzene intoxication, mild poisoning produces headache, dizziness, nausea, stomach pain, anorexia, and hypothermia. In severe cases, pale skin, weakness, blurred vision, and dyspnea occur on exertion. Hemorrhagic tendencies include petechia, easy bmising, and bleeding gums. Bone marrow depression produces a decrease in circulating peripheral erythrocytes and leucocytes (101). Eatafities from chronic exposure show at autopsy severe bone marrow aplasia, and necrosis or fatty degeneration of the heart, fiver, and adrenals (125).  [c.47]

Factors II, VII, IX, XI, and XII are present in Cohn s fraction IX. Recendy, the following not previously reported factors have been detected Fletcher (prekininogenin [prekailikrein]), Fitzgerald (high molecular weight) kininogen (also designated as WiUiams or Flaujeac trait), and Passovoy (bleeding diathesis-prolonged partial thromboplastin time, normal known coagulation factors, autosomal dominant). Roman numerals have not yet been assigned to these factors. Factor VI is not Hsted in the tables because it is obsolete.  [c.170]

See pages that mention the term Bleeding : [c.251]    [c.353]    [c.233]    [c.7]    [c.269]   
Plastics materials (1999) -- [ c.125 , c.140 , c.150 ]