Tyropanoate Sodium

To a mixture of 48.7 parts by weight of ethyl-(7-picolyl)-amine and 36 parts by weight of dry pyridine in 220 parts by weight of dry chloroform is slowly added, while stirring and cooling with ice water, crude acetyltropic acid chloride prepared from 60 parts by weight of tropic acid. To complete the reaction, the mixture is stirred for one additional hour at 23°C. Thereupon the chloroform solution is diluted with 200 parts by weight of ether and agitated with 3 N hydrochloric acid. The weakly Congo acid solution is heated for 1 hour in a steam bath, the acetyl group of the reaction product being thereby split off, and the mixture is filtered over charcoal.  [c.1560]

Ytterby, a village in Sweden near Vauxholm) Yttria, which is an earth containing yttrium, was discovered by Gadolin in 1794. Ytterby is the site of a quarry which yielded many unusual minerals containing rare earths and other elements. This small town, near Stockholm, bears the honor of giving names to erbium, terbium, and ytterbium as well as yttrium.  [c.73]

Ytterby, a village in Sweden) Discovered by Mosander in 1843. Terbium is a member of the lanthanide or "rare earth" group of elements. It is found in cerite, gadolinite, and other minerals along with other rare earths. It is recovered commercially from monazite in which it is present to the extent of 0.03%, from xenotime, and from euxenite, a complex oxide containing 1% or more of terbia.  [c.189]

Sodium terbium borate is used in solid-state devices. The oxide has potential application as an activator for green phosphors used in color TV tubes. It can be used with Zr02 as a crystal stabilizer of fuel cells which operate at elevated temperature. Few other uses have been found.  [c.189]

A) Preparation of p-Hydroxy-p -Methoxybemhydrylidenecyclohexane To a Grignard solution prepared from 110 g of magnesium (4.5 mols) and 840 g of p-bromoanisole (4.5 mols) in one liter of anhydrous ether, there was added dropwise with vigorous agitation 307 g of p-hydroxyphenyl cyclohexyl ketone (1.5 mols) dissolved in one liter of anhydrous ether. Upon completion of the addition the reaction mixture was refluxed for 2.5 hours with agitation, and was then cooled. Thereupon 15 mols of ammonium chloride dissolved in 3 liters of water were added. The ethereal layer was separated, washed with water, dried over anhydrous sodium sulfate and distilled. Yield 370 g. BP 180° to 190°C at 0.1 mm. The substance was recrystallized from a mixture of carbon tetrachloride and petroleum ether. MP 145° to 146°C.  [c.409]

In about 250 cc of liquid ammonia (cooled with dry ice and acetone) are dissolved about 7.5 g of potassium and into the solution acetylene is passed until the blue color has disappeared (about 3 hours). Then slowly a solution or suspension of 3 g of estrone in 150 cc of benzene and 50 cc of ether is added. The freezing mixture is removed, the whole allowed to stand for about 2 hours and the solution further stirred overnight. Thereupon the reaction solution is treated with ice and water, acidified with sulfuric acid to an acid reaction to Congo red and the solution extracted five times with ether. The combined ether extracts are washed twice with water, once with 5% sodium carbonate solution and again with water until the washing water is neutral. Then the ether is evaporated, the residue dissolved in a little methanol and diluted with water. The separated product is recrystallized from aqueous methanol. The yield amounts to 2.77 g. The 17-ethiny I-estradiol-3,17 thus obtained melts at 142°C to 144°C .  [c.589]

For the preparation of mafenide 50 g of acetylbenzylamine are introduced while stirring into 150 cc of chlorosulfonic acid, whereby the temperature is kept below 40°C by external cooling. After several hours storing at ordinary temperature the mixture is heated for 1 hour in the boiling water-bath and after cooling, poured on to ice. Thereupon the 4-acetylamino-ethyl-benzenesulfonic acid chloride precipitates at first in an oily form, but solidifies after short stirring to crystals. The product sucked off and washed with cold water is introduced into a 10% aqueous ammonia solution. Thereby dissolution takes place while heating and after a short time the 4-acetylaminomethyl-benzenesulfonic acid amide precipitates in a crystalline form. After heating to 70°C for 30 minutes the solution is cooled, filtered with suction and washed out. The product is obtained when recrystallized from water or dilute alcohol in colorless crystals melting at 177°C. It is readily soluble in warm water, extremely readily soluble In dilute sodium hydroxide solution.  [c.892]

Preparation of Bot-Methyi-17ot-Hydroxyprogesterone A suspension was made by introducing 2 g of 5a,17a-dihydroxy-6/3-methylallopregnane-3,20-dione into 200 ml of chloroform. The suspension was chilled in an ice bath with stirring, and thereupon hydrogen chloride was bubbled through the reaction mixture for 80 minutes with continuous cooling and stirring. After bubbling in nitrogen for a period of 15 minutes the solution was washed with water, 1 N sodium bicarbonate solution and again with water.  [c.916]

A solution of 33 grams of anhydrous aluminum chloride in 60 grams of nitrobenzene, to which a mixture of 14 grams of phenol and 9.3 grams of hydrochloride of amino-acetonitrile was added, had dry hydrochloric acid gas introduced into it for 3 hours, while stirring and cooling to keep the temperature between 20° and 30°C. The reaction mixture was then poured, with cooling, into 70 cc of water and the deposit obtained was sucked off, washed with acetone and dissolved in 300 cc of water. The solution thus prepared was decolorized with carbon, 50 grams of 30% sodium citrate solution was added to it, and then it was made slightly alkaline with ammonia. Thereupon hydroxy-4 -phenyl-Tamino-2-ethanone crystallized out in the form of leaflets. The yield was 7.7 grams.  [c.1110]

The waxlike condensation product so obtained is mixed with 60 parts by volume of petroleum ether (boiling limits 30°C to 40°C) and agitated with hydrogen in the presence of a little active palladium lead catalyst (Pd-CaC03 catalyst, the activity of which Is reduced by the addition of lead and quinoline). During the operation, the condensation product separates in the form of a voluminous white precipitate. The latter is separated by filtration in the absence of air while adding an inert coarse-grained adsorption agent (for example, aluminum silicate salt for filter purposes), and washed with cooled petroleum ether. Thereupon, the 2-methyl-3-phytyl-1,4-naphthohydroquinone is extracted from the filter cake by means of ether, the ethereal solution is concentrated to 100 parts by volume and the reaction product Is oxidized by stirring the solution with 6.6 parts by weight of silver oxide during 30 minutes. The solution is filtered through sodium sulfate, the latter is rinsed with ether and the solvent is evaporated. There are obtained 5.7 parts by weight of 2-methyl-3-phytyl-1,4-naphthoquinone (vitamin K ) in the form of a golden yellow oil.  [c.1230]

Parts of pyrazine-2,3-dicarboxamide (1 mol) is slurried in 1,000 parts of 1 N aqueous sodium hydroxide. The reaction mixture is heated at 95°C to 98°C until a clear solution results. Thereupon the mixture is cooled with ice to about 5°C and acidified to approximately a pH of 1. The cold reaction mixture is allowed to stand until precipitation of the pyrazlne-2[c.1330]

See pages that mention the term Tyropanoate Sodium : [c.387]    [c.326]    [c.380]    [c.185]    [c.279]    [c.365]    [c.253]    [c.91]    [c.55]    [c.277]    [c.327]    [c.454]    [c.444]    [c.1042]    [c.1230]    [c.1452]   
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Pharmaceutical manufacturing encyclopedia Edition 2  -> Tyropanoate Sodium