Butyronitriles


Nitriles. re-Butyronitrile Benzyl cyanide.  [c.1056]

Butyronitrile 2-Methyl-2-propanol 1.382 1.385 0.786 0.781  [c.1095]

The propensity of nitriles to release cyanide subsequent to metaboHsm is the basis of their acute toxicity. Nitriles that form tertiary radicals at their alpha carbon atoms (eg, isobutyronitrile, 2-methylbutyronitrile) are substantially more acutely lethal than nitriles that form secondary radicals at their alpha carbons (eg, butyronitrile, propionitnle). Cyanohydrins are acutely toxic because they are unstable and release cyanide quickly. Alpha-aminonitriles are also acutely toxic, presumably by analogy with cyanohydrins.  [c.218]

Butyronitrile [109-74-0] M 69.1, b 117.9 , d 0.793, n 1.3846, 1.37954. Treated with cone  [c.152]

A number of ingredients may be used from time to time in PVC formulations. For example, blowing agents such as azodicarbonamide and azodi-iso-butyronitrile are frequently used in the manufacture of cellular PVC.  [c.342]

Dipheny -4-bromo butyronitrile Diphenoxylate HCI  [c.1631]

Sec. amyl acetate 16-9 — Butyronitrile 21-4 0-72  [c.928]

Three skeleton atoms of a hetero-l,3-diene are incorporated into a five-membered ring system on reaction with 1,2 [n,n] compounds (e.g., hydrazines, reaction type 4, equation 10). On further heating in the presence of azobisiso-butyronitrile (AIBN), the bis(trifluoromethyl)-substituted 1,2,4-triazolines are transformed into 5-tnfluoromethyl-l,2,4-triazoles in high yield [t02 (equation 22).  [c.851]

Pd(OAc)2, TPPTS, Et2NH, CH3CN, H2O, 51-100% yield. If the reaction is run in a biphasic system using butyronitrile as the solvent, a dimethylallyl carbamate can be retained, but in a homogeneous system using CH3CN, both groups are cleaved quantitatively.  [c.184]

Catalysts show remarkable product variation in hydrogenation of simple nitriles. Propionitrile, in neutral, nonreactive media, gives on hydrogenation over rhodium-on-carbon high yields of dipropylamine, whereas high yields of tripropylamine arise from palladium or platinum-catalyzed reductions (71). Parallel results were later found for butyronitrile (2S) and valeronitrile (74) but not for long-chain nitriles. Good yields of primary aliphatic amines can be obtained by use of cobalt, nickel, nickel boride, rhodium, or ruthenium in the presence of ammonia (4J 1,67,68,69).  [c.97]

A solution of 27.2 parts of 4-diisopropvlamino-2-phenvl-2-(2-pvridvl)butyronitrile in 200 parts of concentrated sulfuric acid is heated on a steam bath for 4 hours and then poured onto ice. The resultant mixture is alkalized with ION sodium hydroxide, and the pH is adjusted to 6 by the addition of acetic acid. The solution is washed once with benzene before it is alkalized again with ION sodium hydroxide solution. The resultant mixture is extracted with benzene, and the solvent is evaporated from the benzene extract. The resultant residue is dissolved in ethanol and the alcohol solution is treated with charcoal and filtered. Evaporation of the solvent leaves a residue which is recrystallized from hexane to give 4-diisopropvlamino-2-phenvl-2-(2-Pvridvl)butyramide melting at about 94.5°-95°C.  [c.526]


See pages that mention the term Butyronitriles : [c.421]    [c.428]    [c.1095]    [c.218]    [c.224]    [c.269]    [c.273]    [c.278]    [c.141]    [c.203]    [c.217]    [c.152]    [c.378]    [c.83]    [c.202]    [c.214]    [c.204]    [c.75]    [c.257]    [c.520]    [c.945]    [c.945]   
Hydrogenation methods (1985) -- [ c.97 ]