Model programs approach, approach selection


What similarity between the target and template sequences is needed to have a chance of obtaining a useful comparative model This depends on the question that is asked of a model (Section VI). When only the lowest resolution model is required, it is tempting to use one of the statistical significance scores for a given match that is reported by virtually any sequence comparison program to select the best template. However, it is better to proceed with modeling even when there is only a remote chance that the best template is suitable for deriving a model with at least a correct fold. The usefulness of the template should be assessed by the evaluation of the calculated 3D model. This is the best approach, because the evaluation of a 3D model is generally more sensitive and robust than the evaluation of an alignment (Section V) [9].  [c.279]


Guidelines for implementing process safety management systems (1994) -- [ c.134 ]